Anaesthetic inhibiting an ion channel C015 / 6719
Wall Art and Photo Gifts from Science Photo Library
Anaesthetic inhibiting an ion channel C015 / 6719
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres, lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey). Propofol is used for inducing and maintaining general anaesthesia. pLGICs are targeted by general anaesthetics such as propofol which bind to the extracellular interface between the channels five monomers (subunits) and inhibit its action
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9214477
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Anaesthesiology Anaesthetic Analgesia Anesthesia Anesthetic Binding Bound Cell Biology Channel Complex Complexed Cytological Cytology Drug Electron Density General Anaesthesia Inhibiting Inhibition Interacting Interaction Ion Channel Lgic Lgics Ligand Gated Ion Channel Molecules Nmda Receptor Antagonist Pentameric Ligand Gated Ion Channel Pharmacological Pharmacology Plgic Plgics Proteins Proteomics Quaternary Structure Receptor Receptors System Biochemical Biochemistry Cutouts Molecular Model Molecular Structure Protein
EDITORS COMMENTS
This print showcases the intricate structure of propofol anaesthetic drug molecules bound to a pentameric ligand-gated ion channel (pLGIC). The computer-generated model beautifully illustrates the biochemical interaction between these two components within the human body. Propofol, known for its role in inducing and maintaining general anesthesia, acts by inhibiting the action of pLGICs. The image highlights the complex nature of this binding process, with propofol molecules represented as spheres located at the lower left and right corners. The grey-colored pLGIC serves as a backdrop, emphasizing its significance in mediating various physiological responses. By binding to specific sites on this ion channel's extracellular interface, propofol effectively hinders its normal functioning. The scientific artwork not only provides valuable insights into molecular pharmacology but also offers a glimpse into how anesthetics interact with our biological systems. It underscores the importance of understanding these interactions for advancements in anesthesia and analgesia research. Ramon Andrade's masterful creation combines elements from chemistry, medicine, cell biology, and biochemistry to create an aesthetically pleasing yet scientifically informative composition. This visual representation allows us to appreciate both the complexity and beauty inherent in molecular structures that play crucial roles in medical science.
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