Anaesthetic inhibiting an ion channel C015 / 6720
Wall Art and Photo Gifts from Science Photo Library
Anaesthetic inhibiting an ion channel C015 / 6720
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey). Propofol is used for inducing and maintaining general anaesthesia. pLGICs are targeted by general anaesthetics such as propofol which bind to the extracellular interface between the channels five monomers (subunits) and inhibit its action
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9214547
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Anaesthesiology Anaesthetic Analgesia Anesthesia Anesthetic Binding Bound Cell Biology Channel Complex Complexed Cytological Cytology Drug Electron Density General Anaesthesia Inhibiting Inhibition Interacting Interaction Ion Channel Lgic Lgics Ligand Gated Ion Channel Molecules Nmda Receptor Antagonist Pentameric Ligand Gated Ion Channel Pharmacological Pharmacology Plgic Plgics Proteins Proteomics Quaternary Structure Receptor Receptors Ribbon Structure Secondary Structure System Biochemical Biochemistry Cutouts Molecular Model Molecular Structure Protein
EDITORS COMMENTS
This print showcases the intricate structure of propofol anaesthetic drug molecules bound to a pentameric ligand-gated ion channel (pLGIC). The computer-generated model beautifully illustrates the biochemical interaction between the anaesthetic and the ion channel, shedding light on how propofol inhibits its action. Propofol, widely used for inducing and maintaining general anaesthesia, acts by binding to the extracellular interface of pLGIC. By doing so, it effectively hinders the function of this crucial channel composed of five monomers or subunits. This molecular complex is depicted in grey, while propofol molecules are represented in lower left and right corners. The image not only highlights the chemical complexity involved but also emphasizes the significance of this interaction within medicine. Understanding how general anaesthetics like propofol interact with pLGICs provides valuable insights into their pharmacological effects and helps improve patient care during surgical procedures. Ramon Andrade's artistic representation combines elements from biochemistry, cell biology, and pharmacology to create an engaging visual narrative. The ribbon-like structures representing proteins add depth to this scientific artwork while electron density maps provide additional detail about molecular arrangements. Overall, this print offers a glimpse into cutting-edge research at the intersection of chemistry and medicine. It serves as a reminder that science can be both visually stunning and intellectually stimulating.
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