Familial hypercholesterolaemia, diagram
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Familial hypercholesterolaemia, diagram
Familial hypercholesterolaemia. Diagram showing the biochemical processes that take place in a case of the genetic disorder familial hypercholesterolaemia. This disorder leads to higher blood levels of bad cholesterol (low-density lipoprotein, LDL) and associated cardiovascular disease. At left the normal process involves LDL vesicles (yellow) being taken up from blood vessels into cells with LDL receptors (cup-shaped). At right, in a case of familial hypercholesterolaemia, a lack of LDL receptors cuts off the uptake, leading to increased levels of LDL in the blood. The defective gene is the one that encodes the LDL receptor protein
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6335249
© FRANCIS LEROY, BIOCOSMOS/SCIENCE PHOTO LIBRARY
Blood Blood Stream Cardio Vascular Cell Biology Cellular Cholesterol Comparing Comparison Cross Section Cut Away Diagram Genetic Heart Disease Hereditary Heredity Inherited Lipoprotein Metabolic Metabolic Disorder Metabolism Physiological Physiology Quartet Series Uptake Vascular Vesicle Vesicles Abnormal Bio Chemistry Biochemical Cells Circulatory System Condition Genetics Section Sectioned Unhealthy
EDITORS COMMENTS
This print from Science Photo Library showcases the intricate biochemical processes involved in familial hypercholesterolaemia, a genetic disorder that leads to elevated levels of bad cholesterol and subsequent cardiovascular disease. The diagram presents a stark comparison between the normal process on the left and the disrupted process caused by this condition on the right. In the normal process, LDL vesicles are efficiently taken up from blood vessels into cells through cup-shaped LDL receptors. However, in cases of familial hypercholesterolaemia, a lack of these receptors hinders proper uptake, resulting in increased levels of LDL circulating in the bloodstream. The culprit behind this malfunction is identified as a defective gene responsible for encoding the LDL receptor protein. The image's artistic representation beautifully captures both cellular and physiological aspects related to this hereditary disorder. By providing an insightful cross-section view of biological structures within our circulatory system, it allows viewers to comprehend how genetics can impact metabolic pathways and contribute to conditions like heart disease. This visually striking illustration serves as an invaluable resource for medical professionals studying familial hypercholesterolaemia or anyone seeking to understand its underlying mechanisms. It highlights not only the importance of maintaining healthy cholesterol levels but also emphasizes how genetic factors play a significant role in our overall well-being.
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