Chediak-Higashi syndrome, micrograph
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Chediak-Higashi syndrome, micrograph
Chediak-Higashi syndrome. Light micrograph of blood cells in a case of Chediak-Higashi syndrome. The cells include neutrophil white blood cells with abnormal granules, and a promyelocyte (upper centre) with a large azurophilic inclusion in a vacuole. An azurophilic granule (azurophil) or inclusion is one that takes up stains with an azure (dark red) colour. A promyelocyte is a precursor cell that develops into a granulocyte such as a neutrophil. White blood cells are part of the bodys immune system. Chediak-Higashi syndrome is a genetic disorder that leads to a reduction in phagocytosis by white blood cells, increasing susceptibility to infections
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Media ID 9241251
© PR. J. BERNARD/CNRI/SCIENCE PHOTO LIBRARY
Blood Cell Biology Cellular Genetic Granulocyte Granulocytes Haematological Haematology Hereditary Histological Histopathological Histopathology Immune System Immunology Leucocyte Leukocyte Lymphocyte Neutrophils Pathological Pathology White Blood Cell Abnormal Cells Circulation Circulatory System Condition Disorder Genetics Higashi Light Micrograph Light Microscope Unhealthy
EDITORS COMMENTS
This print showcases the intricate details of Chediak-Higashi syndrome, a rare genetic disorder that affects the body's immune system. The light micrograph reveals blood cells in a case of this syndrome, offering valuable insights into its pathological manifestations. The image exhibits neutrophil white blood cells with abnormal granules, hinting at the underlying abnormalities within these crucial defenders of our immune system. A prominent feature is the presence of a promyelocyte in the upper center, characterized by a large azurophilic inclusion enclosed within a vacuole. Azurophilic granules are known for their affinity to azure stains, appearing as dark red hues under microscopic examination. Chediak-Higashi syndrome leads to reduced phagocytosis by white blood cells, rendering individuals more susceptible to infections and compromising their overall immunity. This hereditary disorder poses significant challenges to maintaining optimal health and well-being. Through this remarkable photograph captured using a light microscope, we gain an enhanced understanding of the cellular intricacies associated with Chediak-Higashi syndrome. It serves as a reminder of how genetics can influence our bodies' functioning and highlights the importance of ongoing research in cell biology and immunology to develop effective treatments for such conditions.
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