Caspase-3 and inhibitor F006 / 9457
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Caspase-3 and inhibitor F006 / 9457
Apopain protein and inhibitor. Molecular model of caspase-3, also known as apopain, complexed with an inhibitor. Caspase-3 is a protease, an enzyme that cleaves proteins, that plays a role in apoptosis (programmed cell death). It causes the fragmentation of actin filaments, part of a cells cytoskeleton, and the inactivation of the DNA repairing enzyme poly(ADP-ribose) polymerase. It also activates other caspases as part of the caspase cascade of apoptosis. Caspase-3 is the predominant caspase involved in Alzheimers disease, processing the protein that is associated with neurone death
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9255081
© LAGUNA DESIGN/SCIENCE PHOTO LIBRARY
Alpha Helix Apoptosis Beta Sheet Enzyme Illness Programmed Cell Death Proteomics Strand Tertiary Structure Biochemical Biochemistry Cutouts Disorder Molecular Molecular Model Molecular Structure Protein
EDITORS COMMENTS
This print showcases the intricate molecular model of Caspase-3, also known as apopain, complexed with an inhibitor. Caspase-3 is a vital protease enzyme that plays a crucial role in apoptosis, which refers to programmed cell death. The protein's function involves cleaving proteins and initiating various cellular processes associated with apoptosis. In this image, the white background beautifully highlights the detailed structure of Caspase-3 and its inhibitor F006/9457. The illustration provides valuable insights into the biochemical composition and molecular structure of this essential enzyme involved in numerous biological processes. Caspase-3 exhibits its significance by causing actin filament fragmentation within a cell's cytoskeleton while simultaneously deactivating poly (ADP-ribose) polymerase, an enzyme responsible for DNA repair. Additionally, it activates other caspases as part of the caspase cascade during apoptosis. Notably, Caspase-3 holds particular importance in Alzheimer's disease due to its involvement in processing proteins linked to neuronal death. This makes it a key target for research and potential therapeutic interventions related to this debilitating disorder. The artwork presented here not only represents scientific advancement but also serves as a visual reminder of the critical role played by enzymes like Caspase-3 in maintaining cellular balance and health.
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